Registered Nurse (RN) Endocrine Licensure Exam

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What is the onset and duration of Humalog?

Onset: 15 minutes, Duration: 3 hours
Onset: 2 hours, Duration: 16 hours
Onset: 30 minutes, Duration: 1 hour
Onset: 2 hours, Duration: 24 hours

The correct answer is: Onset: 15 minutes, Duration: 3 hours

Humalog, which is a brand name for insulin lispro, is classified as a rapid-acting insulin. This type of insulin typically begins to work very quickly after injection, which is crucial for managing blood glucose levels, especially after meals. The correct answer provides details on its onset and duration, indicating that it starts to take effect in about 15 minutes after administration and continues to exert its effect for approximately 3 hours. This rapid onset and relatively short duration are essential for mimicking the body's natural insulin response to food intake, allowing for better postprandial blood sugar control. Understanding the pharmacokinetics of insulin types is critical for safe and effective diabetes management. The options that state a longer onset or duration do not align with the characteristics of rapid-acting insulins like Humalog. Such insulins are designed to provide immediate glucose metabolism support, which is vital for patients needing quick adjustments to their blood sugar levels.