Ace the 2026 RN Endocrine Exam – Empower Your Nursing Journey!

Question: 1 / 400

What effect do biguanides have on the liver?

Increase glucose production

Decrease glucose production

Biguanides, such as metformin, primarily work by decreasing glucose production in the liver. This action is crucial for managing type 2 diabetes, as it helps lower blood glucose levels and improve insulin sensitivity. By reducing the amount of glucose released by the liver into the bloodstream, biguanides help to stabilize blood sugar levels. This mechanism not only contributes to better glycemic control but also aids in reducing the overall workload on the pancreas to produce insulin. Thus, the central role of biguanides in glucose metabolism is characterized by their ability to suppress hepatic gluconeogenesis (the production of glucose from non-carbohydrate sources) and improve cellular uptake of glucose in peripheral tissues.

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Increase fat metabolism

Decrease fat metabolism

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