Ace the 2026 RN Endocrine Exam – Empower Your Nursing Journey!

The primary hormone produced by the pancreas that regulates blood glucose levels is insulin. Insulin plays a crucial role in the body's metabolism by facilitating the uptake of glucose into the cells, particularly in muscle and adipose (fat) tissues. When blood glucose levels rise after a meal, the pancreas releases insulin, which helps lower those levels by promoting glucose uptake and storage. It also inhibits the production of glucose by the liver.

This regulatory mechanism is vital for maintaining energy homeostasis. Without adequate insulin or the body's ability to respond to it, as seen in conditions like diabetes mellitus, blood glucose levels can become excessively high, leading to serious health complications.

In contrast, while glucagon is also produced by the pancreas and works to increase blood glucose levels when they are low, it serves a different purpose. Cortisol is a hormone produced by the adrenal glands that plays various roles in metabolism and stress response but is not directly involved in blood glucose regulation like insulin. Thyroid hormone, produced by the thyroid gland, regulates metabolism but also does not directly control blood glucose levels. Understanding these distinctions is crucial for recognizing how different hormones interact in the body's complex system of glucose regulation.